Vault

Vault may refer to:

Architecture

Sports

Arts and entertainment

Fallout (series)

Fallout is a series of post-apocalyptic role-playing video games. It was created by Interplay Entertainment. Although the series is set during the 22nd and 23rd centuries, its atompunk retrofuturistic setting and artwork are influenced by the post-war culture of 1950s America, and its combination of hope for the promises of technology, and lurking fear of nuclear annihilation. A forerunner for Fallout is Wasteland, a 1988 video game of which the Fallout series is regarded to be a spiritual successor. Although the game worlds are different, the background story, inhabitants, locations, and characters draw many parallels.

The first two titles in the series (Fallout and Fallout 2) were developed by Black Isle Studios. Micro Forté and 14 Degrees East's 2001 Fallout Tactics: Brotherhood of Steel is a tactical role-playing game. In 2004, Interplay closed Black Isle Studios, and continued to produce an action game with RPG elements for the PlayStation 2 and Xbox, Fallout: Brotherhood of Steel without Black Isle Studios. A third entry in the main series, Fallout 3, was released in 2008 by Bethesda Softworks. The next role-playing installment of the series, Fallout: New Vegas, came out in 2010 and was developed by Obsidian Entertainment. The newest game in the series, Fallout 4, was announced on June 3, 2015 and was released on November 10, 2015.

Vault (organelle)

The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle whose function is not fully understood. Discovered and successfully isolated by cell biologist Nancy Kedersha and biochemist Leonard Rome of the UCLA School of Medicine in the 1980s, vaults are cytoplasmic organelles which under an electron microscope resemble the arches of a cathedral vault, with 39-fold symmetry. They are present in many types of eukaryotic cells and appear to be highly conserved amongst eukaryotes. Vaults become part of lipid rafts where they may play a role fighting pathogens.

Morphology

Vaults are large ribonucleoprotein particles. About 3 times the size of a ribosome and weighing approximately 13 MDa, they are found in many diverse eukaryotic cells. They measure 34 nm by 60 nm from a negative stain, 26 nm by 49 nm from cryo-electron microscopy, and 35 nm by 59 nm from STEM. The vaults consist primarily of proteins, making it difficult to stain with conventional techniques. The protein structure consists of many major vault proteins (MVP) bound to one of the two minor vault proteins. Two large complexes of several MVP's and a minor vault protein close together to form the barrel-like vault organelle. They also contain small vault RNAs (vRNAs, also known as vtRNAs) of 86–141 bases within.